T-Select MHC Tetramer

MHC Tetramer Products	Custom Service
Human Class I Cancer, Virus, Bacteria etc. Mouse Class I Cancer, Virus, OVA etc. Human Class II Virus, Bacteria, Allergen etc. Mouse Class II MOG, OVA etc. CD1d Human, Mouse HLA-E MR1　 Human Other animals Class I Monkey, Chicken	Class I custom Tetramer Human, Mouse, Monkey, Chicken Class II custom Tetramer Human
MHC custom tetramer kits
QuickSwitch™ Custom Tetramer Kits Kits for preparation of custom tetramers in the laboratory using our proprietary peptide exchange technology.
QuickSwitch™ Peptide Screening Kit For screening MHC binding peptides and creating custom MHC tetramers
TCR Tetramer Products
TCR Tetramer

Most T lymphocytes express a clonal and highly specific antigen receptor (TCR) on the cell surface. TCR (T cell receptor) binds to the MHC-peptide complex and recognizes the antigenic peptide presented in the context of MHC molecules. Because TCR has a low avidity and fast off-rates for MHC-peptide complexes, recombinant soluble monomeric MHC-peptide complexes have not been used to detect antigen-specific T cells. Altman et al. (Science 1996, 274: 94-96) have introduced MHC-peptide tetrameric complexes (so-called MHC tetramers) for detection of antigen-specific T cells. MHC tetramer technology is based on the ability of MHC-peptide complexes to recognize the antigen-specific T cells at a single cell level. This breakthrough technology enables researchers to precisely measure targeted T-cell responses in infectious diseases, cancer, and autoimmune diseases.